Uncovering the Genetic Architectures of Quantitative Traits
نویسندگان
چکیده
منابع مشابه
Uncovering the Genetic Architectures of Quantitative Traits
The aim of a genome-wide association study (GWAS) is to identify loci in the human genome affecting a phenotype of interest. This review summarizes some recent work on conceptual and methodological aspects of GWAS. The average effect of gene substitution at a given causal site in the genome is the key estimand in GWAS, and we argue for its fundamental importance. Implicit in the definition of a...
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ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2016
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2015.10.002